ABSTRACT
Several cardiovascular diseases and arrhythmic disorders have been described in COVID-19 era as likely related to SARS-CoV-2 infection. The prognostic relevance of bradyarrhythmias during the infection has not been yet described and no data are available about long-term heart conduction disorders. A review of literature concerning the association between hypokinetic arrhythmias and COVID-19 from January 2020 to February 2021 was performed. The key-words used for the research were: "sinus node disfunction," "sick sinus syndrome (SSS)," "sino-atrial block," "atrio-ventricular block (AVB)," "bradyarrhythmias," and "COVID-19â³ or "SARS-CoV-2.â³ Excluding "relative bradycardia," a total of 38 cases of bradyarrhythmia related to SARS-CoV-2 infection have been described, even in very young people, requiring in many cases a definitive pacemaker implantation. Furthermore, we report a case of non-hospitalized 47-years old man with a SSS developed as a consequence of mild SARS-CoV-2 infection. While in all described cases heart conduction disorders were found at presentation of the infection or during hospitalization for COVID-19, in our case the diagnosis of SSS was made after the resolution of the infection. Although rarely, heart conduction disorders may occur during COVID-19 and the present case highlights that a cardiological follow up may be desirable even after the resolution of infection, especially in the presence of symptoms suggesting a possible heart involvement.
Subject(s)
Bradycardia/virology , COVID-19/complications , Sick Sinus Syndrome/virology , Bradycardia/physiopathology , Bradycardia/therapy , Electrocardiography , Humans , Male , Middle Aged , Pacemaker, Artificial , Prognosis , SARS-CoV-2 , Sick Sinus Syndrome/physiopathology , Sick Sinus Syndrome/therapySubject(s)
Antiviral Agents/adverse effects , Bradycardia/chemically induced , COVID-19 Drug Treatment , Lopinavir/adverse effects , Ritonavir/adverse effects , Aged , Antiviral Agents/therapeutic use , Bradycardia/virology , Comorbidity , Coronary Disease , Drug Combinations , Humans , Hypertension , Lopinavir/therapeutic use , Male , Ritonavir/therapeutic useABSTRACT
There has been an accumulating evidence of association between COVID-19 (coronavirus disease 2019) infection and cardiovascular complications. We describe a case of a 58-year-old lady with a history of systolic heart failure and COVID-19 infection, who developed persistent symptomatic bradycardia, requiring pacemaker placement as unusual conductive tissue involvement of this novel coronavirus.
Subject(s)
Bradycardia/diagnosis , Bradycardia/virology , COVID-19/complications , Bradycardia/therapy , Diagnosis, Differential , Electrocardiography , Female , Humans , Middle Aged , Pacemaker, Artificial , SARS-CoV-2Subject(s)
Bradycardia/epidemiology , Bradycardia/virology , COVID-19/complications , Hospitalization/statistics & numerical data , Aged , COVID-19/diagnosis , COVID-19/epidemiology , Comorbidity , Female , Humans , Male , Middle Aged , Prevalence , Retrospective Studies , Rome/epidemiology , SARS-CoV-2/geneticsSubject(s)
Bradycardia/virology , COVID-19/complications , Body Temperature , Bradycardia/diagnosis , Female , Heart Rate , Humans , Male , Middle AgedABSTRACT
Coronavirus disease is reported to affect the cardiovascular system. We showed that relative bradycardia was a common characteristic for 54 patients with PCR-confirmed mild-to-moderate coronavirus disease in Japan. This clinical sign could help clinicians to diagnose this disease.